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Monday, March 17, 2008


Monday, March 17, 2008
Tradename: Celebrex®

Generic name: Celecoxib
Classification: NSAID, COX-2 inhibitor

Mode of Action: Inhibits prostaglandin synthesis by decreasing the activity of the enzyme cyclooxygenase-2 (COX-2) which results in decreased formation of prostaglandin precursors. Celecoxib does not inhibit cyclooxygenase-1 (COX-1) at therapeutic concentrations.
Indication and Dosage: 100 mg I tab BID for acute mild to moderate pain.
Side-effects (present on my patient):
CNS: Headache
Cardiovascular: Peripheral edema
Central nervous system: Insomnia, dizziness
Dermatologic: Skin rash
Gastrointestinal: abdominal pain, nausea, flatulence
Neuromuscular & skeletal: Back pain
Cardiovascular: tachycardia,
Hematologic: Anemia,
Neuromuscular & skeletal: Leg cramps, Ocular: Glaucoma, blurred vision,
Renal: Increased BUN, increased creatinine, albuminuria, hematuria, renal calculi
Respiratory: cough,

Adverse Effects (not present on my patient): Alopecia, dermatitis, photosensitivity, pruritus, rash (maculopapular), rash (erythematous), dry skin, urticaria

Contraindications: Hypersensitivity to celecoxib or any component of the formulation

Nursing Intervention/s and teachings:
1. Store drug at room temperature in tightly closed, light resistant container.
2. Tell patient to report history of allergic reactions to sulfonamides, aspirin or other NSAIDs before starting therapy.
3. Instruct patient to take drug with food if stomach upset occurs.
4. Teach the client that drug may cause liver damage.
5. Inform the client that it may take several days before he feels consistent pain relief.
6. Inform client that NSAID’s may cause GI bleeding.