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Showing posts with label Tylenol. Show all posts
Showing posts with label Tylenol. Show all posts

Thursday, June 4, 2009

Tylenol vs. Motrin

Thursday, June 4, 2009
Q. What's better for my child when she has a fever, acetaminophen (Tylenol, Tempra) or ibuprofen (Motrin, Advil)?

A. Although some people will ask how high the fever is before answering that question, in reality, you should probably just use the medicine that has seemed to work the best for your child in the past. If she usually responds well to Tylenol, then stick with it. If Motrin or Advil work better for her, then use one of them instead.

Children's Tylenol is marketed as the 'Pediatrician's First Choice', but ibuprofen supposedly 'reduces fever faster than Children's Tylenol' and 'lasts longer', making Children's Motrin 'the #1 choice of pediatricians for long-lasting fever relief'.

One summary or Critically Appraised Topic of Antipyretics: Ibuprofen vs. Acetaminophen by the Pediatric Evidence-Based Medicine group at the University of Washington concluded that they had 'equivalent effects at maximal doses of each'.

Another study, "Comparison of multidose ibuprofen and acetaminophen therapy in febrile children," showed 'no statistically significant differences in temperature response among the treatment groups' and ' the rates of temperature reduction and maximal reduction of fever after administration of the initial dose were equal for patients receiving 10-mg/kg ibuprofen therapy and 15-mg/kg acetaminophen therapy'.

But another study, 'Efficacy and safety of acetaminophen versus ibuprofen for treating children's pain or fever: A meta-analysis,' concludes that ibuprofen is better and as safe as acetaminophen and "appears to tilt the balance toward ibuprofen." The researchers warn that the "results should be taken with a grain of salt" however, since the studies weren't very large and more research should be done.

Remember that acetaminophen does have the benefit that it comes in a suppository form (Feverall), so you may be able to use it if your child is vomiting or is refusing to take any medications by mouth. And acetaminophen can be used in younger children, while ibuprofen is usually limited to children over six months of age.

Another common question is 'Is it safe to alternate acetaminophen and ibuprofen?' If you are using the correct dosage of each medicine at the correct times, then it is probably safe in most children, although there is no research to prove that it helps or that it is safe. The problem is that it is easy to get confused and give an extra dose of one or the other medicines. And in some children, especially if they are dehydrated or have other medical problems, giving both medications can cause serious side effects, especially affecting the kidneys. If you are alternating fever reducers, then write down a schedule with the times that you are giving the medicines so that the correct medicine is always given at the correct time.

And remember that it is not always necessary to give your child a fever reducer. In most cases, fever is treated as a comfort measure. Treating a fever, especially if it is caused by an infection, will not help your child get better any faster, but it may help make her feel better. If your child has a fever, especially if it is low grade, but does not feel bad, then you don't really need to give her a fever reducer.


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Thursday, April 9, 2009

Acetaminophen: 10 Things You Should Know

Thursday, April 9, 2009
Tylenol (acetaminophen) is a widely used drug which is considered safe when used appropriately. Tylenol safety decreases the chance for undesirable side effects. Safety warnings about Tylenol should be respected. To enhance patient safety, Tylenol must be taken according to directions. If you take Tylenol or may take it in the future, here are 10 things you should know.
1 - Tylenol is a medication prescribed for pain relief and fever reduction.

Tylenol belongs to a class of drugs known as analgesics and antipyretics. Acetaminophen, the generic equivalent of Tylenol, is the most commonly prescribed and widely used analgesic (pain reliever) and antipyretic agent (fever reducer) in the world. Tylenol (acetaminophen) does not have anti-inflammatory properties though. Tylenol is prescribed for many health problems, one of which is arthritis pain.

2 - Acetaminophen, the active ingredient in Tylenol, is contained in more than 100 different products and combination products.

Acetaminophen is contained in countless pain formulations, cold products, sinus preparations, and more (e.g. Sinutab, Midol, Ultracet, Dristan). The wide availability of acetaminophen, sold over-the-counter and in prescription products, make it one of the most common drugs associated with intentional or accidental poisoning. Taking multiple products which contain acetaminophen and exceeding the maximum allowable daily dose can cause serious side effects and can have potentially fatal consequences.

3 - The maximum allowable daily dose of Tylenol (acetaminophen) is 4 grams (or 4000 mg) in adults and 90 mg/kg in children.

Tylenol (acetaminophen) is available as a tablet, chewable tablet, capsule, caplet, geltab, gelcap, extended-release tablet, or liquid suspension to be taken by mouth with or without food. It is also available as a suppository. Regular strength Tylenol is 325 mg per pill. Extra strength Tylenol is 500 mg per pill. For adults, 8 extra strength Tylenol tablets is the maximum allowed per day. If you exceed that amount, you risk serious consequences.

4 - You must be aware of the cumulative effect of taking various products which contain acetaminophen.


As previously explained, many products contain acetaminophen. It is your responsibility to add up the amount of acetaminophen you are ingesting daily, even if from more than one product, to be sure you are not exceeding the daily dose which is allowed. For example, if you take two Darvocets per day, that is equal to 1300 mg acetaminophen since one Darvocet contains 650 mg. acetaminophen. Darvocet contains propoxyphene and acetaminophen. If, in addition, to Darvocet for pain, you also take cold or sinus medication which contains acetaminophen, you must add the total amount ingested (e.g. add up the acetaminophen in both Darvocet and the cold medication) in order to be aware of the cumulative effect. The label on Tylenol recommends that you not take more than one product at a time which contains acetaminophen to ensure that you won't exceed maximum allowable dosages.

5 - Drinking alcoholic beverages while taking acetaminophen is not advised.

If you drink three or more alcoholic beverages every day or have had alcoholic liver disease, ask your doctor if you should take acetaminophen. The combination of alcohol and acetaminophen can be seriously damaging to the liver, with possibly fatal outcomes.

6 - Acetaminophen side effects can be serious. Know when you should call your doctor instead of assuming the problem will disappear.

Certain side effects can be signs of an allergic reaction or a situation which requires immediate medical attention, such as:

* Rash
* Hives
* Itching
* Swelling
* Hoarseness
* Difficulty breathing
* Difficulty swallowing

7 - Symptoms associated with acetaminophen overdose can be serious too, and require immediate medical attention.

The symptoms can occur whether the overdose is accidental or not:

* Nausea
* Vomiting
* Loss of appetite
* Confusion
* Sweating
* Extreme fatigue
* Unusual bleeding or bruising
* Pain in stomach (especially upper right portion)
* Yellowish skin or eyes
* Flu-like symptoms
* Diarrhea
* Irregular heartbeat

8 - There are recommendations and guidelines for how long you should take Tylenol (acetaminophen) if you are self-treating.

Current recommendations suggest that you may take acetaminophen for up to 3 days when treating a fever, and for up to 10 days when treating pain. If symptoms persist beyond that time frame, consult with a doctor to see if you should continue with acetaminophen or change your treatment plan.

9 - Acetaminophen is classified as FDA Pregnancy Category B, meaning, it is unlikely the drug would harm an unborn baby.


If you are pregnant, do not take acetaminophen without discussing it with your doctor. Acetaminophen passes into breast milk. Though it is considered safe to use during breastfeeding, discuss it with your doctor.

10 - When used as directed, Tylenol (acetaminophen) is considered generally safe. That's the bottom line.


When taken according to directions, side effects from acetaminophen are rare. The most serious side effect is liver damage. Kidney toxicity is also a possibility. The risk of liver damage increases with:

* Large doses of acetaminophen
* Chronic use of acetaminophen
* Concomitant use of acetaminophen with alcohol (i.e. taken together) or with other drugs that can also potentially cause liver damage

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